Relaxation of a Simulated Lipid Bilayer Vesicle Compressed by an AFM
Ben M. Barlow, Martine Bertrand, and B\'ela Joos
TL;DR
This study uses coarse-grained molecular dynamics to analyze how lipid bilayer vesicles relax after being compressed by an AFM, revealing a force-dependent relaxation time and matching experimental force-compression behavior.
Contribution
It introduces a simulation approach to study vesicle relaxation under compression, providing insights consistent with experimental observations.
Findings
Relaxation time depends strongly on applied force
Force-compression curves match experimental data
Vesicle behavior under compression is characterized by specific relaxation dynamics
Abstract
Using Coarse-Grained Molecular Dynamics simulations, we study the relaxation of bilayer vesicles, uniaxially compressed by an Atomic Force Microscope (AFM) cantilever. The relaxation time exhibits a strong force-dependence. Force-compression curves are very similar to recent experiments wherein giant unilamellar vesicles were compressed in a nearly identical manner.
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Taxonomy
TopicsLipid Membrane Structure and Behavior · Force Microscopy Techniques and Applications · Characterization and Applications of Magnetic Nanoparticles