Stochastic predator-prey dynamics of transposons in the human genome

TL;DR

This paper models the stochastic predator-prey dynamics of transposons in the human genome, revealing noise-induced oscillations that persist across generations and highlighting the role of fluctuations in mobile genetic elements.

Contribution

It introduces a stochastic model for transposon dynamics that captures noise-induced oscillations, linking ecological concepts to genome behavior.

Findings

Noise-induced predator-prey oscillations predicted by the model

Oscillation time scale exceeds cell replication time

Genomic state transmits across generations

Abstract

Transposable elements, or transposons, are DNA sequences that can jump from site to site in the genome during the life cycle of a cell, usually encoding the very enzymes which perform their excision. However, some transposons are parasitic, relying on the enzymes produced by the regular transposons. In this case, we show that a stochastic model, which takes into account the small copy numbers of the transposons in a cell, predicts noise-induced predator-prey oscillations with a characteristic time scale that is much longer than the cell replication time, indicating that the state of the predator-prey oscillator is stored in the genome and transmitted to successive generations. Our work demonstrates the important role of number fluctuations in the expression of mobile genetic elements, and shows explicitly how ecological concepts can be applied to the dynamics and fluctuations of living genomes.