Clustering of microscopic particles in constricted blood flow

TL;DR

This study uses 3D simulations to analyze how red blood cells and microparticles behave in constricted blood flow, revealing that microparticles tend to cluster near constrictions, which could impact biochemical activity.

Contribution

It demonstrates the opposite behavior of microparticles compared to RBCs in constricted flow and highlights their potential to form clusters affecting physiological processes.

Findings

RBCs are depleted ahead and after constrictions.

Microparticles cluster near constrictions due to dwell time.

Clustering may influence biochemical activity in blood.

Abstract

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted right ahead and after the constriction. Although the RBC mean concentration (hematocrit) is 16.5% or 23.7%, their axial concentration profile is very similar to that of isolated tracer particles flowing along the central axis. Most importantly, however, we find that the stiff microparticles exhibit the opposite behavior. Arriving on a marginated position near the channel wall, they can pass through the constriction only if they find a suitable gap to dip into the dense plug of RBCs occupying the channel center. This leads to a prolonged dwell time and, as a consequence, to a pronounced increase in microparticle concentration right in front of the constriction. For biochemically active particles such as drug delivery agents or activated platelets this clustering may lead to physiologically relevant hot spots of biochemical activity.