Evaluation of a New Vasculature by High Resolution Light Microscopy: Primo Vessel and Node

TL;DR

This study uses high-resolution light microscopy to analyze the primo vascular system, revealing its complex structure and identifying stem cell niches within nodes, suggesting a novel biological role outside bone marrow.

Contribution

It provides detailed morphological insights into the primo vascular system and identifies stem cell niches within nodes, a novel finding in vascular biology.

Findings

Nodes contain microcells expressing stem cell markers.

Nodes serve as stem cell niches outside bone marrow.

Primo vessels have a unique structure with endothelial jackets.

Abstract

The primo vascular system is composed of nodes and vessels. The bundle of sub-vessels of the promo vessel is laid into an external jacket composed of endothelial cells. The node is heterogeneous in nature, composed of twisted sub-vessel bundles that fill up nearly the entire node volume. The enlarged sub-vessel inside the node harbors microcells that express stem cells and stem cells niche markers. We conclude that these microcells are progenitors of multipotent stem cells and the nodes serve as the stem cell niches outside the bone marrow.