Channel Estimation for Diffusive Molecular Communications
Vahid Jamali, Arman Ahmadzadeh, Christophe Jardin, Heinrich Sticht,, and Robert Schober

TL;DR
This paper develops and compares various channel impulse response estimation methods for molecular communication systems, providing theoretical bounds and optimized training sequences to improve detection accuracy.
Contribution
It introduces a comprehensive training-based CIR estimation framework for MC systems, including ML, LSSE, MAP, and LMMSE estimators, along with optimal training sequence design.
Findings
Estimation techniques closely approach the Cramer Rao bounds.
Statistical channel knowledge improves estimation accuracy.
Simulation results validate the effectiveness of proposed methods.
Abstract
In molecular communication (MC) systems, the \textit{expected} number of molecules observed at the receiver over time after the instantaneous release of molecules by the transmitter is referred to as the channel impulse response (CIR). Knowledge of the CIR is needed for the design of detection and equalization schemes. In this paper, we present a training-based CIR estimation framework for MC systems which aims at estimating the CIR based on the \textit{observed} number of molecules at the receiver due to emission of a \textit{sequence} of known numbers of molecules by the transmitter. Thereby, we distinguish two scenarios depending on whether or not statistical channel knowledge is available. In particular, we derive maximum likelihood (ML) and least sum of square errors (LSSE) estimators which do not require any knowledge of the channel statistics. For the case, when statistical…
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