Speckle decorrelation in Ultrasound-modulated optical tomography made by heterodyne holography

TL;DR

This paper theoretically analyzes speckle decorrelation effects in ultrasound-modulated optical tomography using heterodyne holography, highlighting optimal detection conditions for deep tissue imaging.

Contribution

It provides a theoretical framework for detecting tagged photons in UOT with heterodyne holography, including speckle decorrelation considerations and optimal exposure timing.

Findings

Optimal detection sensitivity occurs when exposure time matches decorrelation time.

Heterodyne holography effectively filters untagged photons in UOT.

Speckle decorrelation impacts detection sensitivity and must be considered.

Abstract

Ultrasound-modulated optical tomography (UOT) is a technique that images optical contrast deep inside scattering media. Heterodyne holography is a promising tool able to detect the UOT tagged photons with high efficiency. In this work, we describe theoretically the detection of the tagged photon in heterodyne holography based UOT, show how to filter the untagged photon discuss, and discuss the effect of speckle decorrelation. We show that optimal detection sensitivity can obtain, if the frame exposure time is of the order of the decorrelation time.