Genetic recombination as DNA repair

TL;DR

This paper presents a population genetic model showing that genetic recombination enhances the maintenance of advantageous alleles, increases population fitness, and supports greater genomic complexity, integrating multiple hypotheses about recombination's evolutionary role.

Contribution

It introduces a simple mechanism demonstrating how recombination maintains allele biases, thereby increasing fitness and phenotypic complexity, unifying previous hypotheses.

Findings

Recombination helps maintain larger allele biases.

Recombining populations achieve higher fitness.

Random mating and sexual selection increase complexity capacity.

Abstract

Maintenance of sexual reproduction and genetic recombination imposes physiological costs when compared to parthenogenic reproduction, most prominently: for maintaining the corresponding (molecular) machinery, for finding a mating partner, and through the decreased fraction of females in a population, which decreases the reproductive capacity. Based on principles from information theory, we have previously developed a new population genetic model, and applying it in simulations, we have recently hypothesized that all species maintain the maximum genomic complexity that is required by their niche and allowed by their mutation rate and selection intensity. Applying this idea to the complexity overhead of recombination maintenance, its costs must be more than compensated by an additional capacity for complexity in recombining populations. Here, we show a simple mechanism, where recombination helps to maintain larger biases of alleles frequencies in a population, so the advantageous alleles can have increased frequency. This allows recombining populations to maintain higher fitness and phenotypic efficiency in comparison with asexual populations with the same parameters. Random mating alone already significantly increases the ability to maintain genomic and phenotypic complexity. Sexual selection provides additional capacity for this complexity. The model can be considered as a unifying synthesis of previous hypotheses about the roles of recombination in Muller's ratchet, mutation purging and Red Queen dynamics, because the introduction of recombination both increases population frequencies of beneficial alleles and decreases detrimental ones. In addition, we suggest simple explanations for niche-dependent prevalence of transient asexuality and the exceptional asexual lineage of Bdelloid rotifers.