Detection, numerical simulation and approximate inversion of optoacoustic signals generated in multi-layered PVA hydrogel based tissue phantoms

TL;DR

This paper investigates optoacoustic signals from layered tissue phantoms using experiments and numerical simulations, focusing on signal characterization, effects of diffraction, and approximate inversion methods.

Contribution

It introduces a combined experimental and numerical approach to analyze optoacoustic signals in layered media with negligible scattering, including signal inversion techniques.

Findings

Optoacoustic signals follow exponential decay within layers.

Diffraction significantly affects the observed signals.

Approximate inversion of signals is feasible in the far-field.

Abstract

In this article we characterize optoacoustic signals generated from layered tissue phantoms via short laser pulses by experimental and numerical means. In particular, we consider the case where scattering is effectively negligible and the absorbed energy density follows Beer-Lambert's law, i.e. is characterized by an exponential decay within the layers and discontinuities at interfaces. We complement experiments on samples with multiple layers, where the material properties are known a priori, with numerical calculations for a pointlike detector, tailored to suit our experimental setup. Experimentally, we characterize the acoustic signal observed by a piezoelectric detector in the acoustic far-field in backward mode and we discuss the implication of acoustic diffraction on our measurements. We further attempt an inversion of an OA signal in the far-field approximation.