Bacterial cartels at steady supply

TL;DR

This paper models bacterial communities competing for resources, revealing that stable consortia or 'cartels' emerge, optimizing biomass production and maintaining diversity through a collective equilibrium.

Contribution

It introduces a physical model of bacterial population dynamics with metabolic flux constraints, demonstrating the emergence of stable, cooperative bacterial consortia that maximize biomass at steady resource supply.

Findings

Coexistence of different metabolic types due to population dynamics.

Emergence of bacterial 'cartels' that act as resource-sharing consortia.

Steady supply leads to maximum biomass through collective optimization.

Abstract

Metagenomics has revealed hundreds of bacterial species in almost all microbiota. In a few well-studied cases, bacterial communities have been observed to coordinate their metabolic fluxes. In principle, bacteria can divide tasks to reap the benefits of specialization, as in human economies. However, the benefits and stability of an economy of bacterial specialists are far from obvious. Here, we physically model the population dynamics of bacteria that compete for steadily supplied resources. Importantly, we explicitly model the metabolic fluxes yielding cellular biomass production under the constraint of a limited enzyme budget. In our framework, we find that population dynamics generally leads to the coexistence of different metabolic types, which satisfy an extended competitive exclusion principle (even allowing for adaptive mutation). We establish that these consortia act as cartels, whereby population dynamics pins down resource concentrations at values for which no other strategy can invade. Finally, we propose that at steady supply, cartels of competing strategies automatically yield maximum biomass, thereby achieving a collective optimum.