IMPi: An interactive homology modeling pipeline

TL;DR

IMPi is an interactive homology modeling pipeline that simplifies protein structure prediction, reduces user workload, and allows user engagement at every step, catering to users with varying experience levels.

Contribution

It introduces an interactive pipeline for homology modeling that balances automation with user control, unlike fully automated existing servers.

Findings

Reduces modeling workload for users.

Allows user engagement at all steps.

Accessible via a free online platform.

Abstract

Summary: The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make modeling simpler, but largely exclude users from the process. We present an Interactive Modeling Pipeline (IMPi) for homology modeling. The pipeline simplifies the modeling process and reduces the workload required by the user, while still allowing engagement from the user during every step. Default parameters are given for each step, which can either be modified or supplemented with additional external input. As such, it has been designed for users of varying levels of experience with homology modeling. Availability and implementation: The IMPi site is free for non-commercial use and can be accessed at https://impi.rubi.ru.ac.za. Supplementary information: Documentation available at https://impi.rubi.ru.ac.za/#documentation.