Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: an in vitro study

TL;DR

This study experimentally compares the hemodynamic effects of three coronary bifurcation stenting techniques, revealing how each alters blood flow parameters and potentially impacts clinical outcomes.

Contribution

It provides a detailed in vitro analysis of hemodynamic changes caused by different stenting methods, which was previously not well understood.

Findings

CRU had lowest compliance mismatch but caused detrimental interactions.

PSB maintained flow conditions but increased OSI and RRT significantly.

CUL preserved flow conditions with moderate increases in OSI and RRT.

Abstract

Stent implantation in coronary bifurcations presents unique challenges and currently there is no universally accepted stent deployment approach. Despite clinical and computational studies, to date, the effect of each stent implantation method on the coronary artery hemodynamics is not well understood. In this study the hemodynamics of stented coronary bifurcations under pulsatile flow conditions were investigated experimentally. Three implantation methods, provisional side branch (PSB), culotte (CUL), and crush (CRU), were investigated using time-resolved particle image velocimetry (PIV) to measure the velocity fields. Subsequently, hemodynamic parameters including wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated and the pressure field through the vessel was non-invasively quantified. The effects of each stented case were evaluated and compared against an un-stented case. CRU provided the lowest compliance mismatch, but demonstrated detrimental stent interactions. PSB, the clinically preferred method, and CUL maintained many normal flow conditions. However, PSB provided about a 300% increase in both OSI and RRT. CUL yielded a 10% and 85% increase in OSI and RRT, respectively. The results of this study support the concept that different bifurcation stenting techniques result in hemodynamic environments that deviate from that of un-stented bifurcations, to varying degrees.