Label-free optical quantification of structural alterations in Alzheimer's disease
Moosung Lee, Eeksung Lee, JaeHwang Jung, Hyeonseung Yu, Kyoohyun Kim,, Shinhwa Lee, Yong Jeong, YongKeun Park
TL;DR
This study introduces a label-free holographic microscopy method for high-resolution imaging of mouse brain tissues, enabling quantitative assessment of structural changes associated with Alzheimer's disease.
Contribution
The paper presents a novel, quantitative, label-free imaging technique using holographic microscopy to analyze structural alterations in brain tissues, specifically in Alzheimer's disease models.
Findings
Quantitative measurement of scattering coefficients and anisotropies in brain tissues.
Detection of structural alterations in Alzheimer's disease mouse models.
High-resolution, label-free imaging of whole brain tissue slices.
Abstract
We present a quantitative label-free imaging of mouse whole brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to quantitatively address structural alteration in the brain tissues of mice with Alzheimer's disease.
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