Optical diffraction tomography techniques for the study of cell pathophysiology

TL;DR

Optical diffraction tomography (ODT) offers a powerful, label-free 3D imaging technique that enhances understanding of cell pathophysiology, with recent studies demonstrating its broad biological and medical applications.

Contribution

This paper reviews the principles of ODT and highlights recent research applications in cell pathophysiology, emphasizing its potential in biological and medical studies.

Findings

ODT provides quantitative, label-free 3D imaging of cells.

Recent studies show ODT's effectiveness in studying cell pathophysiology.

ODT has broad applications in biology and medicine.

Abstract

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction tomography (ODT) have demonstrated the potential for the study of various cells with its unique advantages of quantitative and label-free imaging capability. To provide insight on this rapidly growing field of research and to discuss its applications in biology and medicine, we present the summary of the ODT principle and highlight recent studies utilizing ODT with the emphasis on the applications to the pathophysiology of cells.