A statistical theory of coil-to-globule-to-coil transition of a polymer chain in the mixture of good solvents

TL;DR

This paper develops a statistical model to describe the coil-globule-coil transition of a polymer in mixed solvents, revealing temperature-dependent regimes and confirming the enthalpy-entropy nature of co-nonsolvency.

Contribution

It introduces a comprehensive off-lattice model accounting for various interactions and thermodynamics, providing new insights into the reentrant transition phenomena of polymers in mixed solvents.

Findings

Reentrant coil-globule-coil transition at high temperatures.

First-order phase transition at lower temperatures.

Solution heat capacity changes align with calorimetry data.

Abstract

We present an off-lattice statistical model of a single polymer chain in mixed solvent media. Taking into account a polymer conformational entropy, renormalization of solvent composition near the polymer backbone, the universal intermolecular excluded volume and Van-der-Waals interactions within the self-consistent field theory the reentrant coil-to-globule-to-coil transition (co-nonsolvency) has been described in this paper. For convenience we split the system volume in two parts: the volume occupied by the polymer chain and the volume of bulk solution. Considering the equilibrium between two sub-volumes, the polymer solvation free energy as a function of radius of gyration and co-solvent mole fraction within internal polymer volume has been obtained. Minimizing the free energy of solvation with respect to its arguments, we show two qulitatively different regimes of co-nonsolvency. Namely, at sufficiently high temperature a reentrant coil-to-globule-to-coil transition proceeds smoothly. On the contrary, when the temperature drops below a certain threshold value a coil-globule transition occurs in the regime of first-order phase transition, i.e., discontinuous changes of the radius of gyration and the local co-solvent mole fraction near the polymer backbone. We show that, when the collapse of polymer chain takes place, the entropy and enthalpy contributions to the solvation free energy of globule strongly grow. From the first principles of statistical thermodynamics we confirm earlier speculations based on the MD simulations results that the co-nonsolvency is the essentially enthalpic-entropic effect and caused by enthalpy-entropy compensation. We show that the temperature dependences of solution heat capacity change due to the solvation of polymer chain are in qualitative agreement with the Differential scanning calorimetry data for PNIPAM in aqueous methanol.