A non-linear subdiffusion model for a cell-cell adhesion in chemotaxis

TL;DR

This paper introduces a novel non-linear, non-Markovian subdiffusion model incorporating cell-cell adhesion and chemotaxis, deriving and analyzing a fractional master equation to understand stationary cell density distributions.

Contribution

It develops a new fractional subdiffusive model that accounts for adhesion and chemotaxis, with systematic derivation and stationary analysis of the governing equations.

Findings

Adhesion influences stationary cell density distribution.

Derived fractional master equation captures subdiffusive transport with adhesion.

Stationary solutions reveal the role of adhesion in cell aggregation.

Abstract

The purpose of this work is to propose a non-Markovian and nonlinear model of subdiffusive transport that involves adhesion affects the cells escape rates form position x, with chemotaxis. This leads the escape rates to be dependent on the particles density at the neighbours as well as the chemotactic gradient. We systematically derive subdiffusive fractional master equation, then we consider the diffusive limit of the fractional master equation. We finally solve the resulted fractional subdiffusive master equation stationery and analyse the role of adhesion in the resulted stationary density.