Modulation of diffusion rate of therapeutic peptide drugs using graphene oxide membranes

TL;DR

This study explores how graphene oxide membranes can be used to control the diffusion rate of peptide drugs, combining experiments and modeling to enable tailored drug release for therapeutic use.

Contribution

It introduces a combined experimental and numerical approach to modulate peptide drug diffusion through graphene oxide membranes, advancing drug delivery technology.

Findings

Diffusion rate depends non-linearly on membrane properties.

Modeling confirms control over drug release timing.

Tunable GO membranes can optimize therapeutic delivery.

Abstract

We investigate diffusion of a peptide drug through Graphene Oxide (GO) membranes that are modeled as a porous layered laminate constructed from aligned flakes of GO. Our experiments using a peptide drug show a tunable non-linear dependence of the peptide concentration upon time. This is confirmed using numerical simulations with a diffusion equation accounting for the photothermal degradation of fluorophores and an effective percolation model. This modeling yields an interpretation of the control and delay of drug diffusion through GO membranes. The ability to modulate the density of hydrogel-like GO membranes to control drug release rates could be a step forwards in tailoring drug release properties of the hydrogels for therapeutic applications.