Discriminative Subnetworks with Regularized Spectral Learning for Global-state Network Data
Xuan Hong Dang, Ambuj K. Singh, Petko Bogdanov, Hongyuan You and, Bayyuan Hsu

TL;DR
This paper introduces a spectral learning algorithm to identify discriminative subnetworks in global-state network data, enabling effective classification by optimizing a low-dimensional subspace that captures shared topology and discriminative features.
Contribution
It proposes a novel spectral graph learning method with a matrix eigen-decomposition approach to discover discriminative subnetworks in global-state networks, addressing the exponential subnetwork search challenge.
Findings
Efficient algorithm for subnetwork discrimination via eigen-decomposition.
Effective classification of global network states using learned low-dimensional subspace.
Addresses the exponential complexity of subnetwork search with a spectral approach.
Abstract
Data mining practitioners are facing challenges from data with network structure. In this paper, we address a specific class of global-state networks which comprises of a set of network instances sharing a similar structure yet having different values at local nodes. Each instance is associated with a global state which indicates the occurrence of an event. The objective is to uncover a small set of discriminative subnetworks that can optimally classify global network values. Unlike most existing studies which explore an exponential subnetwork space, we address this difficult problem by adopting a space transformation approach. Specifically, we present an algorithm that optimizes a constrained dual-objective function to learn a low-dimensional subspace that is capable of discriminating networks labelled by different global states, while reconciling with common network topology sharing…
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Taxonomy
TopicsComputational Drug Discovery Methods · Bioinformatics and Genomic Networks · Gene Regulatory Network Analysis
