Mathematical model of the interaction between baroreflex and cerebral autoregulation

TL;DR

This paper develops a mathematical model to explore the interaction between baroreflex and cerebral autoregulation, aiming to better understand their relationship and implications for cerebrovascular health.

Contribution

It introduces a novel mathematical framework to simulate how baroreflex influences cerebral blood flow dynamics, filling a gap in understanding their interaction.

Findings

Model successfully simulates BR effects on cerebral blood flow

Provides insights into BR and CA interaction mechanisms

Potential clinical implications for cerebrovascular disease prognosis

Abstract

Baroreflex (BR) and cerebral autoregulation (CA) are two important mechanisms regulating blood pressure and flow. However, the functional relationship between BR and CA in humans is unknown. Since BR impairment is an adverse prognostic indicator for both cardiac and cerebrovascular diseases it would be of clinical interest to better understand the relationship between BR and CA. Motivated by this observation we develop a simple mathematical framework aiming to simulate the effects of BR on the cerebral blood flow dynamics.