Simultaneous Acquisition of Multi-nuclei Enhanced NMR/MRI by Solution State Dynamic Nuclear Polarization

TL;DR

This paper demonstrates a novel liquid-state DNP method enabling simultaneous multi-nuclei enhancement and acquisition in NMR/MRI, significantly improving sensitivity and providing comprehensive molecular information in a single measurement.

Contribution

It introduces a simple approach for simultaneous multi-nuclei DNP enhancement and acquisition, including sodium ion enhancement and low-field multi-nuclear imaging, which were not previously reported.

Findings

Large simultaneous DNP enhancements for nuclei like 1H and 23Na.

First report of sodium ion enhancement in liquid-state DNP.

First simultaneous imaging of 19H and 31P at low field.

Abstract

Dynamic nuclear polarization (DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance (NMR) of various molecules. Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarizations of all kinds of nuclei in the system. The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy (MRS) and image (MRI). Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority. We have observed very large simultaneous DNP enhancements for different nuclei, such as 1H and 23Na, 1H and 31P, 19F and 31P, especially for the first time to report sodium ion enhancement in liquid. We have also obtained the simultaneous imaging of 19H and 31P at low field by solution-state DNP for the first time. This method can obtain considerably complementary structure-determination information of miscellaneous biomolecules from a single measurement. It can also be used in combination with the fast acquisition schemes and quantitative analysis with reduced scan time.