Polycrystalline para-terphenyl scintillator adopted in a $\beta^-$ detecting probe for radio-guided surgery

TL;DR

This paper presents a novel intraoperative beta-minus detecting probe using a polycrystalline para-terphenyl scintillator, enabling rapid detection of small cancerous residuals during radio-guided surgery.

Contribution

It introduces a new scintillator-based probe optimized for beta-minus detection, improving intraoperative cancer detection capabilities.

Findings

Detects 0.1 ml cancer residuals in seconds

Operates effectively with diagnostic-level radiotracer activity

Uses a custom electronics system for surgeon feedback

Abstract

A radio-guided surgery technique exploiting $\beta^-$ emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharmaceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting $\beta^-$ radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical fibres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.