Reaction-Diffusion Degradation Model for Delayed Erosion of Cross-Linked Polyanhydride Biomaterials

TL;DR

This paper presents a theoretical reaction-diffusion model explaining the delayed erosion in cross-linked polyanhydride biomaterials, highlighting the nonlinear water-dependent degradation rate as the key factor.

Contribution

It introduces a novel reaction-diffusion model incorporating nonlinear degradation kinetics to explain delayed erosion in polyanhydrides.

Findings

Long induction interval due to nonlinear water dependence

Breakdown of standard rate equations in modeling degradation

Insights into microscopic factors affecting erosion behavior

Abstract

We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently synthesized and studied cross-linked polyanhydrides. Various kinetic mechanisms are incorporated in the model in an attempt to explain the experimental data for the mass loss profile. Our key finding is that the observed long induction interval is attributable to the nonlinear dependence of the degradation rate constants on the local water concentration, which essentially amounts to the breakdown of the standard rate-equation approach, potential causes for which are then discussed. Our theoretical results offer physical insights into which microscopic studies will be required to supplement the presently available macroscopic mass-loss data in order to fully understand the origin of the observed behavior.