The impact of cancer on the neural activity

TL;DR

This paper models how cancerous growth in brain tissue reduces neuronal firing rates, showing that increased cancer proliferation leads to decreased neural activity under various stimuli.

Contribution

It introduces a cellular automaton model to simulate the effects of cancer on neural activity and explores how different proliferation rates impact firing rates.

Findings

Cancer proliferation decreases neuronal firing rate

Neural activity reduction varies with external stimuli

Model provides insights into cancer's impact on brain function

Abstract

We study the impact of the decrease in the neural population on the neuronal firing rate. We propose a cellular automaton model from cancerous growth in a brain tissue and the death of neurons due absence of cells that help support to neurons. We use this model to study how the firing rate changes when the neuronal networks is under different external stimuli and the cancerous cells have different proliferation rate. Our work shows that the cancer proliferation decreases the neuronal firing rate.