Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing

TL;DR

This paper introduces a novel water-immersed, nucleobase-functionalized graphene nanoribbon sensor that leverages Watson-Crick base pairing and graphene's strain-to-electrical signal conversion for high-speed, accurate DNA sequencing.

Contribution

It presents a new sensor design combining nucleobase functionalization with graphene nanoribbons and demonstrates its potential for realistic, high-speed DNA sequencing without complex data processing.

Findings

Significant electrical signal variation in response to nucleotide strains

Sensor operates effectively at ambient conditions

Potential for high-speed, accurate DNA sequencing

Abstract

We propose a water-immersed nucleobase-functionalized suspended graphene nanoribbon as an intrinsically selective device for nucleotide detection. The proposed sensing method combines Watson-Crick selective base pairing with graphene's capacity for converting anisotropic lattice strain to changes in an electrical current at the nanoscale. Using detailed atomistic molecular dynamics simulations, we study sensor operation at ambient conditions. We combine simulated data with theoretical arguments to estimate the levels of measurable electrical signal variation in response to strains and determine that the proposed sensing mechanism shows significant promise for realistic DNA sensing devices without the need for advanced data processing, or highly restrictive operational conditions.