Two different modes of oscillation in a gene transcription regulatory network with interlinked positive and negative feedback loops

TL;DR

This paper investigates a gene regulatory network with linked positive and negative feedback loops, revealing two distinct oscillation modes with unique frequency and amplitude characteristics, and demonstrating the network's flexibility in switching modes.

Contribution

It identifies two different oscillation modes in a gene network with feedback loops and shows how parameter tuning enables switching between these modes.

Findings

The network exhibits two oscillation modes with distinct frequency and amplitude behaviors.

Negative and positive feedback loops provide additional functional advantages.

The network can switch modes by adjusting key parameters.

Abstract

We study the oscillatory behaviour of a gene regulatory network with interlinked positive and negative feedback loop. Frequency and amplitude are two important properties of oscillation. Studied network produces two different modes of oscillation. In one mode (mode 1) frequency remains constant over a wide range amplitude and in other mode (mode 2) the amplitude of oscillation remains constant over a wide range of frequency. Our study reproduces both features of oscillations in a single gene regulatory network and show that the negative plus positive feedback loops in gene regulatory network offer additional advantage. We identified the key parameters/variables responsible for different modes of oscillation. The network is flexible in switching between different modes by choosing appropriately the required parameters/variables.