Single Molecule Transistor based Nanopore for the detection of Nicotine

TL;DR

This paper proposes a novel nanopore-based detection method using a Single Molecular Transistor to identify Nicotine molecules electronically, offering a potential alternative to traditional chemical chromatography techniques.

Contribution

The study introduces a unique SMT nanopore approach that detects Nicotine via charge stability diagrams, enabling identification of molecular orientation and position electronically.

Findings

Charge stability diagrams can detect Nicotine presence.

Molecular orientation affects the charge stability regions.

Method offers a non-chemical detection alternative.

Abstract

A nanopore based detection methodology was proposed and investigated for the detection of Nicotine. This technique uses a Single Molecular Transistor (SMT) working as a nanopore operational in the Coulomb Blockade regime. When the Nicotine molecule is pulled through the nanopore area surrounded by the Source(S), Drain(D) and Gate electrodes, the charge stability diagram can detect the presence of the molecule and is unique for a specific molecular structure. Due to the weak coupling between the different electrodes which is set by the nanopore size, the molecular energy states stay almost unaffected by the electrostatic environment that can be realised from the charge stability diagram. Identification of different orientation and position of the Nicotine molecule within the nanopore area can be made from specific regions of overlap between different charge states on the stability diagram that could be used as an electronic fingerprint for detection. This method could be advantageous and useful to detect the presence of Nicotine in smoke which is usually performed using chemical chromatography techniques.