An in-host model of HIV incorporating latent infection and viral mutation

TL;DR

This paper develops a detailed mathematical model of HIV within a host, including latent infection and mutation, analyzes its long-term behavior, and examines the impact of antiretroviral therapy.

Contribution

It introduces a novel seven-component in-host HIV model that incorporates latent infection and viral mutation, with a rigorous analysis of its dynamics.

Findings

Model predicts long-term infection outcomes

Antiretroviral drugs significantly alter viral dynamics

Insights into treatment strategies for HIV

Abstract

We construct a seven-component model of the in-host dynamics of the Human Immunodeficiency Virus Type-1 (i.e, HIV) that accounts for latent infection and the propensity of viral mutation. A dynamical analysis is conducted and a theorem is presented which characterizes the long time behavior of the model. Finally, we study the effects of an antiretroviral drug and treatment implications.