MicroRNAs -- targeting and target prediction
Takaya Saito, P{\aa}l S{\ae}trom
TL;DR
This review discusses the mechanisms of animal microRNA targeting, compares features with siRNAs, and describes available computational prediction tools for identifying miRNA targets.
Contribution
It provides a comprehensive overview of miRNA targeting features and evaluates current prediction tools, highlighting advances in understanding miRNA-mRNA interactions.
Findings
Features of animal miRNA targeting are characterized.
Current prediction tools are summarized and evaluated.
Insights into miRNA and siRNA functional similarities are provided.
Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.
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