DNA-Based Storage: Trends and Methods
S. M. Hossein Tabatabaei Yazdi, Han Mao Kiah, Eva Ruiz Garcia, Jian, Ma, Huimin Zhao, Olgica Milenkovic
TL;DR
This paper reviews current DNA storage techniques, introduces new coding schemes to improve reliability, and analyzes methods to optimize DNA-based data storage systems.
Contribution
It presents novel constrained coding schemes tailored for DNA storage, enhancing error correction and data integrity in archival and random access applications.
Findings
New coding schemes reduce error rates in DNA storage
Sequences designed to avoid address patterns improve data retrieval
Enhanced base content balance increases storage stability
Abstract
We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random access DNA storage channels. The mathematical basis of our work is the construction and design of sequences over discrete alphabets that avoid pre-specified address patterns, have balanced base content, and exhibit other relevant substring constraints. These schemes adapt the stored signals to the DNA medium and thereby reduce the inherent error-rate of the system.
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