Large-data global generalized solutions in a chemotaxis system with tensor-valued sensitivities
Michael Winkler

TL;DR
This paper establishes the existence of global generalized solutions for a chemotaxis system with tensor-valued sensitivities in arbitrary dimensions, overcoming the lack of gradient structure through new a priori bounds and compactness arguments.
Contribution
It introduces a generalized solution concept for chemotaxis systems with tensor sensitivities and proves global existence in any dimension under mild conditions, extending previous 2D results.
Findings
Proved global existence of solutions for tensor-valued sensitivities.
Developed new a priori bounds based on gradient estimates.
Extended results to higher dimensions beyond 2D.
Abstract
A chemotaxis system possibly containing rotational components of the cross-diffusive flux is studied under no-flux boundary conditions in a bounded domain , , with smooth boundary, where the evolution of the signal is determined by consumption through cells. In contrast to related Keller-Segel-type problems with scalar sensitivities, in presence of such tensor-valued sensitivities this system in general apparently does not possess any useful gradient-like structure. Accordingly, its analysis needs to be based on new types of a priori bounds. Using a spatio-temporal estimate for the gradient of the logarithm of the cell density as a starting point, we derive a series of compactness properties of solutions to suitably regularized versions of the system. Motivated by these, we develop a generalized solution concept which requires solutions to satisfy very…
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Taxonomy
TopicsMathematical Biology Tumor Growth · Gene Regulatory Network Analysis · Cellular Mechanics and Interactions
