Interaction of Alamethicin Pores in DMPC Bilayers
Doru Constantin, Guillaume Brotons, Ansgar Jarre, Chenghao Li, Tim, Salditt
TL;DR
This study uses x-ray scattering to analyze how alamethicin pores interact within DMPC bilayers, revealing a lipid-mediated repulsive interaction consistent with theoretical predictions.
Contribution
It provides the first experimental measurement of the interaction potential between alamethicin pores in lipid bilayers.
Findings
Repulsive lipid-mediated interaction with a range of ~30 Å
Contact interaction value of 2.4 k_BT
Qualitative agreement with theoretical models
Abstract
We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius corresponding to the geometric radius of the pore, we find a repulsive lipid-mediated interaction with a range of {\AA} and a contact value of 2.4 . This result is in qualitative agreement with recent theoretical models.
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Taxonomy
TopicsLipid Membrane Structure and Behavior · Advancements in Transdermal Drug Delivery · Force Microscopy Techniques and Applications