Monolayer characteristics of chitosan assembled in Langmuir films mixed with arachidic acid

TL;DR

This study investigates the formation of stable monolayer films of biodegradable chitosan mixed with arachidic acid using Langmuir-Blodgett technique, highlighting potential applications in drug delivery due to improved stability.

Contribution

It demonstrates that mixing chitosan with fatty acids like arachidic acid enables stable monolayer formation, which was previously challenging for pure chitosan.

Findings

Chitosan forms stable monolayers when mixed with arachidic acid

The mixed films are potentially useful for drug delivery applications

The stability of the films is suitable for biological use

Abstract

Here we report the monolayer characteristics of a biodegradable polymer chitosan using Langmuir-Blodgett film technique. Usually chitosan has not form stable monolayer film. However they form stable monolayer film when mixed with fatty acid. Our result may be useful for the biological application of chitosan mainly in drug delivery. Since, the stability during the time of drug delivery is one of the important criteria for the choice of biomaterials suitable for forming the carrier film matrix and the barrier films.