Hydrodynamic Limits for Spatially Structured Interacting Neurons

TL;DR

This paper derives a hydrodynamic limit for a spatially structured stochastic neuron model, showing that the empirical distribution converges to a PDE describing the evolution of membrane potentials.

Contribution

It introduces a novel spatially dependent neuron model without mean-field assumptions and proves convergence to a nonlinear hyperbolic PDE.

Findings

Empirical distribution converges to a PDE as   0.

The limiting PDE is of hyperbolic type, capturing neuron interactions.

Electrical synapses induce synchronization effects in the model.

Abstract

In this paper we study the hydrodynamic limit for a stochastic process describing the time evolution of the membrane potentials of a system of neurons with spatial dependency. We do not impose on the neurons mean-field type interactions. The values of the membrane potentials evolve under the effect of chemical and electrical synapses and leak currents. The system consists of $\epsilon^{-2}$ neurons embedded in $[0,1)^2$, each spiking randomly according to a point process with rate depending on both its membrane potential and position. When neuron $i$ spikes, its membrane potential is reset to a resting value while the membrane potential of $j$ is increased by a positive value $\epsilon^2 a(i,j)$, if $i$ influences $j$. Furthermore, between consecutive spikes, the system follows a deterministic motion due both to electrical synapses and leak currents. The electrical synapses are involved in the synchronization of neurons. For each pair of neurons $(i,j)$, we modulate this synchronizing strength by $\epsilon^2 b(i,j)$, where $b(i,j)$ is a nonnegative symmetric function. On the other hand, the leak currents inhibit the activity of all neurons, attracting simultaneously their membrane potentials to the resting value. In the main result of this paper is shown that the empirical distribution of the membrane potentials converges, as the parameter $\epsilon$ goes to zero, to a probability density $\rho_t(u,r)$ which is proved to obey a non linear PDE of Hyperbolic type.