Differential Evolution Approach to Detect Recent Admixture
Konstantin Kozlov, Dmitry Chebotarov, Mehedi Hassan, Martin Triska,, Petr Triska, Pavel Flegontov, Tatiana Tatarinova
TL;DR
This paper introduces reAdmix, an advanced online tool that accurately infers biogeographic origins of highly admixed individuals, addressing a critical need in genetics, anthropology, and medicine.
Contribution
The paper presents a novel, computational approach using differential evolution to improve ancestry inference for individuals with complex mixed origins.
Findings
reAdmix effectively identifies multiple biogeographic origins.
The tool enhances accuracy over existing methods.
It is accessible online for broad research use.
Abstract
The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.