First Passage processes in cellular biology

TL;DR

This paper reviews the first passage process formalism in cellular biology, explaining its fundamentals and applications in biophysical systems like channel transport, receptor binding, and cell growth.

Contribution

It provides a unified framework for understanding and applying first passage techniques to diverse biological phenomena, integrating existing methods.

Findings

Clarifies the FP formalism within a unified framework

Demonstrates practical applications in biophysical systems

Highlights analytical techniques for biological processes

Abstract

Often sharp changes in cellular behavior are triggered by thresholded events, i.e., by the attainment of a threshold value of a relevant cellular or molecular dynamical variable. Since the governing variable itself typically undergoes noisy or stochastic dynamics, there is a corresponding variability in the times when the same change occurs in each cell of a population. This time is called the "first passage" time and the corresponding process is a "first passage" (FP) process, referring to the event when a random variable first passes the threshold value. In this review we first present and elucidate fundamentals of the FP formalism within a unified conceptual framework, which naturally integrates the existing techniques. We then discuss applications thereof, with emphasis on the practical use of FP techniques in biophysical systems. Our focus here is on covering a diverse set of analytical techniques; the number of reviewed biological applications is thus limited, out of necessity. We focus on three specific areas: channel transport; receptor binding and adhesion; and single-cell growth and division.