On Preparing a List of Random treatment Assigns

TL;DR

This paper introduces a computer-based method for generating strong randomized treatment assignment lists in clinical trials, ensuring balanced treatment groups and analyzing their randomness properties.

Contribution

It presents a novel threshold-based approach for creating strong randomized lists, enhancing the reliability of treatment allocation in clinical studies.

Findings

The method guarantees exactly equal treatment numbers.

It produces strong randomized lists with desirable randomness properties.

Applicable in early-stage clinical trials and bioequivalence tests.

Abstract

This paper presents the foundations of a computer oriented approach for preparing a list of random treatment assignments to be adopted in randomised controlled trials. Software is presented which can be applied in the earliest stage of clinical trials and bioequivalence assays. This allocation of patients to treatment in clinical trials ensures exactly equal treatment numbers. The investigation of the randomness properties of an assignment leads to the concept of a 'strong randomised list'. The new approach introduced in this note is based on thresholds and produces a strong randomised list of treatment assignments.