Polarisation of cells and soft objects driven by mechanical interactions: Consequences for migration and chemotaxis

TL;DR

This paper presents a mechanical model explaining how cells polarize and move on substrates, highlighting the role of oscillating forces, substrate interactions, and noise, with implications for understanding chemotaxis.

Contribution

It introduces a generic mechanical model for cell polarization and motility driven by oscillating force multipoles and substrate interactions, revealing new insights into cell guidance mechanisms.

Findings

Cell polarization emerges from long-range mechanical interactions.

Optimal motility occurs when oscillation frequency matches system relaxation time.

Chemotaxis can be achieved by modulating motion persistence, not velocity.

Abstract

We study a generic model for the polarisation and motility of self-propelled soft objects, biological cells or biomimetic systems, interacting with a viscous substrate. The active forces generated by the cell on the substrate are modelled by means of oscillating force multipoles at the cell-substrate interface. Symmetry breaking and cell polarisation for a range of cell sizes naturally `emerge' from long range mechanical interactions between oscillating units, mediated both by the intracellular medium and the substrate. However, the harnessing of cell polarisation for motility requires substrate-mediated interactions. Motility can be optimised by adapting the oscillation frequency to the relaxation time of the system or when the substrate and cell viscosities match. Cellular noise can destroy mechanical coordination between force-generating elements within the cell, resulting in sudden changes of polarisation. The persistence of the cell's motion is found to depend on the cell size and the substrate viscosity. Within such a model, chemotactic guidance of cell motion is obtained by directionally modulating the persistence of motion, rather than by modulating the instantaneous cell velocity, in a way that resembles the run and tumble chemotaxis of bacteria.