The search for candidate relevant subsets of variables in complex systems

TL;DR

This paper introduces the Dynamical Cluster Index, an information-theoretic method for identifying relevant variable subsets in complex systems using observational data, applicable across various domains without prior system knowledge.

Contribution

The paper presents a novel, model-free method based on the Dynamical Cluster Index to detect relevant variable groups in complex systems from time series data.

Findings

Successfully applied to diverse systems like neural networks and signaling pathways

Effective in uncovering system organization without prior knowledge

Applicable to both model-generated and real-world data

Abstract

In this paper we describe a method to identify "relevant subsets" of variables, useful to understand the organization of a dynamical system. The variables belonging to a relevant subset should have a strong integration with the other variables of the same relevant subset, and a much weaker interaction with the other system variables. On this basis, extending previous works on neural networks, an information-theoretic measure is introduced, i.e. the Dynamical Cluster Index, in order to identify good candidate relevant subsets. The method does not require any previous knowledge of the relationships among the system variables, but relies on observations of their values in time. We show its usefulness in several application domains, including: (i) random boolean networks, where the whole network is made of different subnetworks with different topological relationships (independent or interacting subnetworks); (ii) leader-follower dynamics, subject to noise and fluctuations; (iii) catalytic reaction networks in a flow reactor; (iv) the MAPK signaling pathway in eukaryotes. The validity of the method has been tested in cases where the data are generated by a known dynamical model and the Dynamical Cluster Index method is applied in order to uncover significant aspects of its organization; however it is important to stress that it can also be applied to time series coming from field data without any reference to a model. Given that it is based on relative frequencies of sets of values, the method could be applied also to cases where the data are not ordered in time. Several indications to improve the scope and effectiveness of the Dynamical Cluster Index to analyze the organization of complex systems are finally given.