Mathematical Modelings for Angiogenesis - A Cellular Automaton Model and its Continuous Model

TL;DR

This paper introduces a cellular automaton model and its continuous counterpart to simulate angiogenesis, capturing key behaviors of endothelial cells and emphasizing the importance of distance-dependent cell interactions.

Contribution

It presents a novel cellular automaton model for angiogenesis and derives an analytically solvable differential equation model, advancing understanding of EC dynamics.

Findings

Model reproduces blood vessel elongation and bifurcation.

Distance-dependent cell interactions are crucial for EC behavior.

Continuous model aligns with cellular automaton results.

Abstract

Based on recent experiments with time-lapse fluorescent imaging, we propose a cellular automaton model for the dynamics of vascular endothelial cells (ECs) in angiogenic morphogenesis. The model successfully reproduces cell mixing behavior, elongation and bifurcation of blood vessels. The results suggest that the two-body interaction between ECs, which is repulsive in short distance and become attractive in moderately long distance, is essential to the dynamics of ECs, in particular, to the cell mixing behavior. The corresponding analytically solvable differential equation model is also proposed.