On a semilinear elliptic boundary value problem arising in cardiac electrophysiology

TL;DR

This paper develops a mathematical framework to detect small inhomogeneities in heart tissue by analyzing boundary voltage perturbations in a nonlinear elliptic model, aiding in the diagnosis of ischemic regions.

Contribution

It provides a novel asymptotic formula for boundary voltage changes caused by small inhomogeneities in a semilinear elliptic model of cardiac electrophysiology.

Findings

Derived an asymptotic boundary perturbation formula for nonlinear problems.

Established well-posedness and energy estimates for the model.

Proposed ideas for reconstructing inhomogeneities from boundary data.

Abstract

In this paper we provide a representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction in a simplified {\em monodomain model} describing the electric activity of the heart. We derive such a result in the case of a nonlinear problem. Our long-term goal is the solution of the inverse problem related to the detection of regions affected by heart ischemic disease, whose position and size are unknown. We model the presence of ischemic regions in the form of small inhomogeneities. This leads to the study of a boundary value problem for a semilinear elliptic equation. We first analyze the well-posedness of the problem establishing some key energy estimates. These allow us to derive rigorously an asymptotic formula of the boundary potential perturbation due to the presence of the inhomogeneities, following an approach similar to the one introduced by Capdeboscq and Vogelius in \cite{capvoge} in the case of the linear conductivity equation. Finally, we propose some ideas of the reconstruction procedure that might be used to detect the inhomogeneities.