Towards a Radio-guided Surgery with $\beta^{-}$ Decays: Uptake of a somatostatin analogue (DOTATOC) in Meningioma and High Grade Glioma

TL;DR

This paper explores a new radio-guided surgery method using beta-minus radiation, focusing on the uptake of a somatostatin analogue in brain tumors to assess its feasibility for tumor detection.

Contribution

It investigates the uptake of 90Y-DOTATOC in meningioma and high-grade glioma, providing foundational data for developing beta-minus radiation-based surgical techniques.

Findings

90Y-DOTATOC shows significant uptake in meningioma and glioma tissues.

Feasibility of beta-minus radiation for tumor detection is supported by uptake data.

Potential for improved surgical precision with this technique.

Abstract

A novel radio guided surgery (RGS) technique for cerebral tumors using $\beta^{-}$ radiation is being developed. Checking the availability of a radio-tracer that can deliver a $\beta^{-}$ emitter to the tumor is a fundamental step in the deployment of such technique. This paper reports a study of the uptake of 90Y labeled (DOTATOC) in the meningioma and the high grade glioma (HGG) and a feasibility study of the RGS technique in these cases.