Spherical-Wave Far-Field Interferometer for Hard X-Ray Phase Contrast Imaging

TL;DR

This paper introduces a spherical-wave inline Mach-Zehnder interferometer capable of high-contrast, low-dose phase contrast imaging over large areas using divergent x-ray sources, demonstrated with biological specimens.

Contribution

It presents the first tabletop spherical-wave interferometer for broadband, divergent x-ray sources, enabling extended-area phase contrast imaging in medical applications.

Findings

Achieved phase contrast images at a clinical dose with 6 nanoradian wavefront bending sensitivity.

Unresolved structures visible at lower doses compared to conventional radiography.

Demonstrated imaging of biological specimens with improved contrast.

Abstract

Low dose, high contrast x-ray imaging is of general interest in medical diagnostic applications. X-ray Mach-Zehnder interferometers using collimated synchrotron beams demonstrate the highest levels of phase contrast under a given exposure dose. However, common x-ray sources emit divergent cone beams. Here, we developed a spherical-wave inline Mach-Zehnder interferometer for phase contrast imaging over an extended area with a broadband and divergent source. The first tabletop system was tested in imaging experiments of a mammographic accreditation phantom and various biological specimens. The noise level of the phase contrast images at a clinical radiation dose corresponded to a 6 nano radian bending of the x-ray wavefront. Un-resolved structures with conventional radiography and near-field interferometer techniques became visible at a fraction of the radiation dose.