Active patterning and asymmetric transport in a model actomyosin network

TL;DR

This study presents a minimal physical model of actomyosin networks that captures pattern formation and transport mechanisms through motor-filament interactions, buckling, and network connectivity, revealing insights into cellular structural dynamics.

Contribution

The paper introduces a new minimal model combining nonlinear filament elasticity and motor activity to explain pattern formation and transport in cytoskeletal networks.

Findings

Motor-driven buckling localizes collapse events.

Dynamic motor action stabilizes 2D patterns below percolation threshold.

Simulations suggest a novel intracellular transport mechanism in 3D networks.

Abstract

Cytoskeletal networks, which are essentially motor-filament assemblies, play a major role in many developmental processes involving structural remodeling and shape changes. These are achieved by nonequilibrium self-organization processes that generate functional patterns and drive intracellular transport. We construct a minimal physical model that incorporates the coupling between nonlinear elastic responses of individual filaments and force-dependent motor action. By performing stochastic simulations we show that the interplay of motor processes, described as driving anti-correlated motion of the network vertices, and the network connectivity, which determines the percolation character of the structure, can indeed capture the dynamical and structural cooperativity which gives rise to diverse patterns observed experimentally. The buckling instability of individual filaments is found to play a key role in localizing collapse events due to local force imbalance. Motor-driven buckling-induced node aggregation provides a dynamic mechanism that stabilizes the two dimensional patterns below the apparent static percolation limit. Coordinated motor action is also shown to suppress random thermal noise on large time scales, the two dimensional configuration that the system starts with thus remaining planar during the structural development. By carrying out similar simulations on a three dimensional anchored network, we find that the myosin-driven isotropic contraction of a well-connected actin network, when combined with mechanical anchoring that confers directionality to the collective motion, may represent a novel mechanism of intracellular transport, as revealed by chromosome translocation in the starfish oocyte.