Rigidity and stability of spheres in the Helfrich model

TL;DR

This paper classifies spherical solutions in the Helfrich model for bilayer membranes, focusing on red blood cells, and analyzes their rigidity and stability to better understand spherocytes and related conditions.

Contribution

It provides a complete classification of spherical solutions in the Helfrich model and analyzes their rigidity and stability, specifically for red blood cell shapes.

Findings

Complete classification of spherical solutions in the Helfrich model.

Analysis of rigidity and stability of spherocytes.

Insights into spherocytosis and red blood cell morphology.

Abstract

The Helfrich functional, denoted by H^{c_0}, is a mathematical expression proposed by Helfrich (1973) for the natural free energy carried by an elastic phospholipid bilayer. Helfrich theorises that idealised elastic phospholipid bilayers minimise H^{c_0} among all possible configurations. The functional integrates a spontaneous curvature parameter c_0 together with the mean curvature of the bilayer and constraints on area and volume, either through an inclusion of osmotic pressure difference and tensile stress or otherwise. Using the mathematical concept of embedded orientable surface to represent the configuration of the bilayer, one might expect to be able to adapt methods from differential geometry and the calculus of variations to perform a fine analysis of bilayer configurations in terms of the parameters that it depends upon. In this article we focus upon the case of spherical red blood cells with a view to better understanding spherocytes and spherocytosis. We provide a complete classification of spherical solutions in terms of the parameters in the Helfrich model. We additionally present some further analysis on the rigidity and stability of spherocytes.