In-vitro iontophoresis of pinneal Sus scrofa skin and its transport flux modelling as influenced by time and current density

TL;DR

This study develops an enhanced flux model for transdermal drug delivery via iontophoresis, accounting for the effects of time and current density on drug transport through pig skin.

Contribution

It introduces a combined flux model that integrates current density and time dependence, improving upon existing models for iontophoretic drug transport.

Findings

Flux increases with current density and time.

The exponential model accurately fits flux data.

The combined model predicts transport behavior more precisely.

Abstract

The purpose of this study was to enhance the existing time dependent flux model for the transdermal iontophoretic transport of drugs. This study evaluated the flux data as influenced by time and current density. In vitro iontophoresis performed on the piglet (Sus scrofa) necropsy-taken medial scapha pinneal skin that mounted in the U shaped sink chamber. Iontophoresis of atenolol with a constant dose of 1000 ppm was implemented for 3 hours with acceptor phase sampling every 30 minutes. Data were analised based on exponential fitting of each current density value to produce a current density dependent flux model. This model then combined with the time differential model of flux to produce a flux model that takes account of both current density and time.