Beta sheet propensity and the genetic code

TL;DR

This paper explores how the genetic code may inherently protect against amyloid fibril formation by analyzing mutation patterns beyond traditional GC-content metrics.

Contribution

It introduces a novel approach to mutation analysis, focusing on the genetic code's role in preventing amyloid fibril formation.

Findings

Genetic code may provide partial protection against amyloid fibrils.

Traditional mutation analysis based on GC-content is expanded.

New insights into mutation patterns and protein aggregation risk.

Abstract

So far mutations analysis was performed in terms of transitions and trasversions, so on the basis of the molecule, or in terms of GC-content and isochors, through the quantification of GC->AT mutations over AT->GC mutations. We tried a different approach hypothesizing that probably we are partially protected (by the genetic code) from amyloid fibrils formation.