Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: a pilot study

TL;DR

This study introduces a two-compartment model extending the Farhi equation to estimate physiological parameters from breath VOC analysis, validated with experimental data on isoprene and deuterated isoprene-D5.

Contribution

The paper presents a novel modeling approach that links breath VOC concentrations to physiological parameters, accounting for non-zero inhaled concentrations.

Findings

Model successfully estimates endogenous production and metabolic rates.

Validation with experimental data supports model accuracy.

Extends existing breath analysis models to more realistic inhalation scenarios.

Abstract

In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.