Budding of domains in mixed bilayer membranes

TL;DR

This paper presents a theoretical model explaining how lipid bilayer membranes form buds and domains due to curvature and composition coupling, revealing complex phase behaviors including tricritical points and coexistence regions.

Contribution

It introduces a mean-field model incorporating curvature-composition coupling to analyze domain budding and phase diagrams in lipid bilayers, highlighting new phase behaviors.

Findings

Identification of fully-budded, dimpled, and flat states.

Discovery of tricritical behavior and three-phase coexistence regions.

Analysis of phase diagrams based on membrane parameters.

Abstract

We propose a model that accounts for budding behavior of domains in lipid bilayers, where each of the bilayer leaflets has a coupling between its local curvature and local lipid composition. The compositional asymmetry between the two monolayers leads to an overall spontaneous curvature. The membrane free-energy contains three contributions: bending energy, line tension, and a Landau free-energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams which contain fully-budded, dimpled and flat states. In particular, for some range of membrane parameters, the phase diagrams exhibit a tricritical behavior as well as three-phase coexistence region. The global phase diagrams can be divided into three types and are analyzed in terms of the curvature-composition coupling parameter and domain size.