Liquid refractive index sensing independent of opacity using an optofluidic sensor based on diffraction

TL;DR

This paper presents a multi-functional optofluidic sensor capable of independently measuring refractive index and opacity of biofluids, with improved range and separation capabilities demonstrated through simulations and experiments.

Contribution

The paper introduces a novel optofluidic sensor that separates refractive index sensing from opacity measurement and extends the measurement range using high-index polymer gratings.

Findings

Broader refractive index measurement range achieved

Refractive index sensing separated from opacity sensing

Sensor demonstrated effective in simulations and experiments

Abstract

We have implemented a multi-functional optofluidic sensor that can monitor changes in the refractive index and pressure of biofluid simultaneously and can detect free-solution molecular interaction in-situ. In this paper, we demonstrate two major improvements of this sensor proven by both simulation and experiments. One improvement is the broader measurement range of refractive index by making the diffraction grating with high-index polymer. The other improvement is the separation of refractive index sensing from opacity sensing by using the relative power ratio of diffraction orders. This simple, compact and low-cost multi-functional optofluidic sensor has the potential to be used for in-situ biofluid monitoring.