Stochastic synchronization of genetic oscillators induced by miRNA
Saurabh Kumar Sharma, Shakti Nath Singh, Md. Jahoor Alam, and R.K., Brojen Singh
TL;DR
This paper investigates how miRNA influences the synchronization of genetic oscillators, identifying optimal coupling conditions and the modulatory role of miRNA concentration in stochastic systems.
Contribution
It introduces a stochastic formalism to analyze miRNA-induced synchronization and identifies optimal coupling parameters for maximal synchronization.
Findings
Optimal coupling constant for strongest synchronization
MiRNA concentration modulates synchronization activity
Stress activity dominates below optimal coupling
Abstract
We study two important roles of miRNA as stress inducer and synchronizing agent in regulating diffusively coupled genetic oscillators within stochastic formalism and competition between them. We identify optimal value of coupling constant at which the rate of synchronization is strongest, below this value sychronizing activity dominates stress activity, and above it stress activity destroys synchronizing pattern. The concentration of miRNA maintained in individual oscillator modulates the synchronization activity achieved by diffusing miRNA.
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Taxonomy
TopicsRNA Research and Splicing · Gene Regulatory Network Analysis · stochastic dynamics and bifurcation