The co-existence of states in p53 dynamics driven by miRNA

TL;DR

This paper investigates how miRNA influences p53 dynamics, revealing the coexistence of stabilized and oscillating states driven by miRNA levels, which indicates the system's ability to survive in different functional states.

Contribution

It demonstrates the co-existence of multiple p53 dynamic states induced by miRNA levels within a specific concentration range, highlighting complex regulatory behavior.

Findings

Co-existence of stabilized and oscillating p53 states driven by miRNA.

Multiple p53 dynamic states correspond to cell survival and apoptosis.

System's behavior depends on miRNA concentration within a certain range.

Abstract

The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model network incorporating reactive oxygen species (ROS) is studied. The study shows that miRNA drives p53 dynamics at various states, namely, stabilized states and oscillating states (damped and sustain oscillation). We found the co-existence of these states within certain range of the concentartion level of miRNA in the system. This co-existence in p53 dynamics is the signature of the system's survival at various states, normal, activated and apoptosis driven by a constant concentration of miRNA.